History

In 1992 Clinical Investigations was founded by Dr. Gerhard Krejci. Clinical Investigations has constantly grown since. In 2002, Dr. Georg Mathis together with two partners founded Appletree AG, a niche CRO focusing on ophthalmology and medical device investigations, in a later stage also on regulatory affairs worldwide. In April 2013, both companies – having about the same size – merged into Appletree CI Group with headquarters in Winterthur (Switzerland). In January 2014, Appletree CI Group acquired the Swiss Biostatistics & Data Management company Brunner & Hess. In 2019, in the course of a strategic reorganisation, Biostatistics and Data Management services were discontinued, and several subsidiaries closed. From 2019 the focus was put on clinical development and related services.

Appletree CI Group is present in 9 European countries. The Group is privately owned.

1992

Foundation of Clinical Investigations Ltd, London, UK – International Clinical Trials Projects

1994

Foundation of Clinical Investigations Kft, Budapest, Hungary – Medical Headquarters for Trials in Central Europe

2002

Foundation of Appletree AG, by Dr. G. Mathis – A niche CRO for ophthalmic studies and medical device investigations covering Europe

2009

Foundation of Clinical Investigations EOOD, Bulgaria

2013

Foundation of Appletree sprl, Belgium
(specialized in global Regulatory Affairs)

Merger of Clinical Investigations Group and Appletree AG to Appletree CI Group
– It’s a CRO offering full service for clinical trials inclusive regulatory affairs. Focusing on ophthalmology, dermatology, medical device investigations and pediatric studies

Foundation of Appletree CI, sp.z.o.o., Poland

2014

Integration of Brunner & Hess Data Management and Biostatistic – CSO offering all clinical trials services inhouse.

2017

Divestment

2019

Focus on Clinical & Consulting Services, offering full service together with preferred partners.

Management

Appletree’s executive committee believes in lean management. They delegate responsibi…

Staff profile

The team is our asset. We understand the importance of highly qualified and experienc…

Awards

At Appletree CI Group, we are proud of the awards we won and the recognition we gaine…

References

We take pride in supporting our customers and partners. In the last 20 years, we perf…

Archive

Best in Ophthalmological & Dermatological Medicine 2016

Most Innovative CRO Company 2015